Spontaneous Unilateral Carotid Dissection: A Case Report of a Rare Complication in a Patient With Graves' Disease

Carotid artery dissection (CAD) is a recognized cause of ischemic stroke (IS) in young adults. At the same time, hyperthyroidism, particularly in the context of thyroid storm (TS), can also lead to IS through mechanisms related and unrelated to atrial fibrillation (AF). However, the coexistence of CAD and thyrotoxicosis is extremely rare. We report the case of a 45-year-old woman with Graves' disease (GD) who presented with TS, developing IS secondary to left CAD. The patient had a history of poorly controlled hyperthyroidism despite being on methimazole and beta-blocker therapy. Upon admission, she presented with fever, diarrhea, tremor, and palpitations. Physical examination revealed bilateral exophthalmos, goiter, and AF. Thyroid function tests confirmed TS, and treatment was initiated with antithyroid drugs, betablockers, glucocorticoids, and plasma exchange. Three days later, she developed focal neurological symptoms, and imaging studies revealed multiple ischemic lesions in the left middle cerebral artery territory. Further investigation confirmed left internal CAD, with no evidence of trauma or other underlying conditions to explain the dissection, leading to the conclusion that GD was the likely cause. The patient underwent thyroidectomy with subsequent clinical improvement, and she was discharged in good condition with long-term anticoagulation due to the presence of AF. This case highlights a rare association between GD and CAD, emphasizing the importance of cons

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XRWLeS

Hydrophobic deep eutectic solvents (HDES) are emerging as sustainable and tunable alter­ natives to conventional organic solvents due to their low toxicity, environmental compat­ ibility, and adjustable physicochemical properties. This study investigated the influence of hydrogen-bond donor type on the structure, surface properties, antibacterial activity, and extraction performance of menthol-based HDES, assessing their potential for environmen­ tal remediation. Five HDES were synthesized using levulinic acid, acetic acid, lactic acid, oleic acid, and linalool as hydrogen-bond donors and characterized by nuclear magnetic resonance and infrared spectroscopy. Quantum-chemical calculations predicted donor re­ activity and hydrogen-bonding interactions. Surface properties, including interfacial ten­ sion, contact angles, drop volume, and surface energy components, were measured, and polarity was determined using a solvatochromic probe. Antibacterial activity was tested against Gram-positive and Gram-negative bacteria and Candida species. Extraction effi­ ciency of methylene blue and diclofenac from aqueous solutions was evaluated to assess pollutant removal. The HDES exhibited low interfacial tension and dispersive-dominated surface energy, confirming their hydrophobic nature. Polarity was tunable according to hydrogen-bond donor type, with menthol–linalool HDES showing the strongest antibac­ terial activity. Extraction efficiencies ranged from 65 to 84% for methylene blue and 7 to 52% for diclofenac, highlighting the importance of donor selection, polarity, and vis­ cosity. Greenness evaluation using BAGI and ComplexGAPI tools confirmed superior environmental performance of the synthesized HDES. Menthol-based HDES thus provide multifunctional properties, combining tunable polarity, bioactivity, and efficient pollutant extra ction. They represent a promising class of environmentally friendly solvents for water purification, analytical applications, and sustainable chemical processes. Highlights ● Menthol-based HDES were synthesized using five hydrogen bond donors. ● The HDES exhibited low interfacial tension and dispersive surface energy. ● Solvent polarity was tuned by selecting hydrogen bond donors (ENR ≈ 52–57 kcal/mol). ● Menthol–linalool HDES showed the strongest antibacterial activity. 1 3 V. Vorobyova et al. ● The HDES efficiently extracted methylene blue and diclofenac.

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High-efficiency design and optimization of 2 T monolithic polymer/polymer tandem solar cells using SCAPS-1D simulations

Inthisstudy,wepresentanovel2 Tmonolithicpolymer/polymertandemsolarcell(TSC)modelbasedon experimentallyvalidatedsub-celldesignscomposedentirelyofOSC/OSCpolymers.Theindividualsubcellshavebeencalibratedagainstexperimentaldata,resultinginpowerconversionefficiencies(PCE)of 10.33%forthefrontcelland21.72%forthebackcell.ThelowercellcontainsaPM6:Y6activelayerinan ITO/Cu2O/PM6:Y6/SnO2/Agconfiguration,whiletheupperpolymercellisdesignedwithaconventional ITO/PEDOT:PSS/PM7:PIDT/PDINN/Agstructure,withPM7:PIDTastheabsorberlayer.Simulations wereperformedusingthe1DSCAPStooltoindividuallyoptimizetheperformanceofeachsub-cell. Extensiveinvestigationwascarriedoutonbandalignment,defectdensity,activelayerthicknessandthe selectionofelectronandholetransportlayers(ETLsandHTLs).Theeffectso ftemperature,shuntresistance andseriesresistanceonthetwosub-cellswerealsoanalyzedtoimprovestabilityandperformance.The resultingtandemstructureexhibitedashortcircuitcurrentdensity(JSC)of11.685 mA cm−2,anopencircuit voltage(VOC)of2.0721 V,afillfactorof82.823%andaPCEof20.054%,positioningitasapromising candidateforflexible,greenandhighlyefficienttandemsolarcells.Theseresultshighlightthepotentialof ourdesigntoadvancetheperformancebenchmarksoforganictandemsolarcells. Nomenclature table with units. Nomenclature Meaning Units HTL Hole Transport Layer ETL Electron Transport Layer Eg Energy Bandgap (eV) χ Electron Affinity (eV) ε Relative Permittivity Nc Effective Density of States in Conduction Band (1/cm3) Nv Effective Density of

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Study on the uranium adsorption and reusability characteristics of amidoximated polypropylene‑acrylonitrile‑acrylic acid fibrous adsorbent

The kinetics and thermodynamics of the U(VI) adsorption process on amidoximated polypropylene-acrylonitrile-acrylic acid (AOPP-AN-AAc) fiber adsorbent were investigated by static adsorption at different temperatures. The process of uranium adsorption by the adsorbent was fitted to the pseudo-second-order kinetic model and the pseudo-second-order rate constant and the pseudo activation energy at different temperatures were determined. The thermodynamic properties of the U(VI) adsorption process by the adsorbent were also evaluated. The optimum conditions of adsorption were determined by studying the effects of U(VI) concentration, solution pH, temperature and stirring conditions on the adsorption equilibrium. The desorption and regeneration properties of U(VI) adsorb ed on the adsorbent were evaluated in different media.

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Biosynthesis Optimization of Antibacterial‑Magnetic Iron Oxide Nanoparticles from Bacillus megaterium

The occurrence of antibiotic resistance on common bacterial agents and the need to use new generations of antibiotics have led to the use of various strategies for production. Taking inspiration from nature, using bio-imitation patterns, in addition to the low cost of production, is advantageous and highly accurate. In this research, we were able to control the temperature, shake, and synthesis time of the synthesis conditions of Bacillus megaterium bacteria as a model for the synthesis of magnetic iron nanoparticles and optimize the ratio of reducing salt to bacterial regenerating agents as well as the concentration of salt to create iron oxide nanoparticles with more favorable properties and produced with more antibacterial properties. Bacterial growth was in vestigated by changing the incubation times of pre-culture and overnight culture in the range of the logarithmic phase. The synthesis time, salt ratio, and concentration were optimized to achieve the size, charge, colloidal stability, and magnetic and antibacterial properties of nanoparticles. The amount of the effective substance produced by the bacteria was selected by measuring the amount of the active substance synthesized using the free radical reduction (DPPH) method. With the help of DPPH, the duration of the synthesis was determined to be one week. Characterizations such as UV–vis spectroscopy, FTIR, FESEM, X-ray, and scattering optical dynamics were performed and showed that the nanoparticles synthesized with a salt concentration of 80 mM and a bacterial suspension to salt ratio of 2:1 are smaller in size and have a light scattering index, a PDI index close to 0.1, and a greater amount of reducing salt used in the reaction during one week compared to other samples. Moreov er, they had more antibacterial properties than the concentration of 100 mM. As a result, better characteristics and more antibacterial properties than common antibiotics were created on E. coli and Bacillus cereus.

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[¹⁷⁷Lu]Lu-DOTA-TATE plus long-acting octreotide versus high‑dose long-acting octreotide for the treatment of newly diagnosed, advanced grade 2–3, well-differentiated, gastroenteropancreatic neuroendocrine tumours (NETTER-2): an open-label, randomised, phase 3 study

(Abstract not found)

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Comparison of Robotics and Navigation for Clinical Outcomes After Minimally Invasive Lumbar Fusion

(Abstract not found)

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How do older adults experience pet companionship? A qualitative study of the affective relationship with pets and its effect on the mental health of older adults during the Covid-19 pandemic

This study aimed to explore the affective relationship of older adults with their pets during the COVID-19 pandemic; and to assess how this contributed to their mental health. This qualitative study included 351 participants aged 65–88 years from Portugal, the United Kingdom, and Spain. All interviews went through content analysis. Findings indicated five themes: (1) Enabling a meaningful affective relationship (86%); (2) Strengthening affective sharing with partner (68%); (3) Easing new affective relationships (61%); (4) Enhancing sensory stimuli and physical touch (55%); and; (5) Feeling physical pleasure (23%). Three main themes emerged from the content analysis regarding the second objective: (1) Fewer depressive and anxiety symptoms (73%); (2) Fewer feelin gs of loneliness (68%); and (3) Fewer mood swings (43%). The affective relationship between older adults and their pets was relevant during the COVID-19 pandemic since it solidified affective relation­ ships with their partners and fostered the creation of new relationships. Additionally, it contributed to a deeper affective relationship with them­ selves, in terms of sensory stimuli, physical touch, and physical pleasure. Owning a pet improved mental health symptoms, namely those associated with depression, anxiety, and mood swings. Introduction The world population is graying. Between 2015 and 2050, the proportion of the world’s population over 60 years will nearly double from 12 to 22% (2.1 billion),

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Left bundle branch area versus conventional pacing after transcatheter valve implant for aortic stenosis: the LATVIA study

(Abstract not found)

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“ Double-edged sword ” : the effect of cultural distance on post-disaster tourism destination recovery

Purpose – Some researchers have found that disasters may have a ‘‘blessing in disguise effect’’ that some disaster sites transformed into more popular tourism destinations; however, no studies have analyzed the heterogeneity of the ‘‘blessing in disguise effect’’. This paper aims to explore and determine the effect of cultural distance on international inbound tourist arrivals to a post-disaster tourist destination that could explain this heterogeneous phenomenon. Design/methodology/approach – This study used a threshold regression model and a differences-indifferences (DID) approach to analyze 2000–2016 international tourist arrival data from 13 main origin countries to Sichuan Province before and after the 2008 Wenchuan Earthquake in China. Find ings – The effect of cultural distance on post-disaster inbound arrivals from the various origin countries followed a non-linear U-shaped ‘‘double-edged sword’’ pattern rather than displaying a simple linear relationship. Most notably, the disaster appeared to have a more positive effect on arrivals from countries with larger cultural distances, while the effect on arrivals from countries with shorter cultural distances was negative. Originality/value – This study found that cultural distance could explain the heterogeneous ‘‘blessing in disguise’’ phenomenon, and it had both positive and negative impacts on tourism destination recovery; that is, a definite ‘‘double-edged sword effect’’ of cultural distance was found, which could help destination marketing organizations and management departments to design appropriately targeted marketing for post-disaster tourism destination recovery.

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Real-world use of anifrolumab in systemic lupus erythematosus: A retrospective study from a Danish tertiary center (2022 – 2025)

Objective: To evaluate the real-world safety, efficacy, and steroid-sparing effects of anifrolumab in patients with systemic lupus erythematosus (SLE) treated at a tertiary referral center in Denmark. Methods: We conducted a retrospective observational study of all SLE/discoid lupus patients who received at least one infusion of anifrolumab between May 2022 and February 2025 at Aarhus University Hospital. Clinical and laboratory data were extracted from electronic medical records at baseline, 3 months, 6 months, and last follow-up. Disease activity was assessed using SLEDAI-2K, Physician's Global Assessment (PGA), LLDAS, and DORIS criteria. Results: Thirty-six patients (94% female, mean age 52 years) received anifrolumab for a mean of 462 days. Median SLEDAI2K d ecreased from 8 at baseline to 2 at month 3, and to 0 at both month 6 and last follow-up. The proportion achieving SLEDAI-2K = 0 increased from 0% at baseline to 52% at both 6 months and last follow-up. At the last follow-up, 87% achieved both PGA ≤0.5 and LLDAS, while 70% achieved DORIS remission. Prednisolone doses declined by >50%. Skin and musculoskeletal involvement showed the greatest improvement. Herpesvirus-related infections were the most frequent adverse events; two severe cases occurred, though treatment was generally continued. Conclusion: Anifrolumab was associated with rapid, sustained disease control and significant steroid-sparing effects. Herpesvirus infections were common, underscoring the importance

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Fluorescent carbon dot embedded polystyrene particle: an alternative to fluorescently tagged polystyrene for fate of microplastic studies: a preliminary investigation

Laboratory-based experiments using fluorescently labeled microplastic particles are common techniques for studying the fate of microplastic in the environment. However, the stability of fluorescent dyes used to label microplastic particles becomes an issue and can create artifacts due to the leaching of dyes. Here, we synthesize fluorescent polystyrene (PS) particles by embedding carbon dots (CDs), thus eliminating problems associated with the stability of dyes. Polystyrene particles were synthesized by mini-emulsion polymerization. Hydrophobic CDs were obtained from candle soot and were dispersed in the monomer before the mini-emulsion polymerization. The carbon dot embedded polymer particles (CDPS) show blue fluorescence on UV 370 nm excitation. This material could be a viable and more reliable alternative to fluorescently labeled PS particles in microplastic studies.

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Analysis https://doi.org/10.1038/s41893-022-01025-0 Limited quantity and quality of steel supply in a zero-emission future

(Abstract not found)

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Magnetorheological Shear Thickening Polishing Characteristics for Ti-6Al-4V using Multi-Pole Coupling Magnetic Field: A Comprehensive Experimental Study

Magnetorheological shear thickening polishing (MRSTP) demonstrates significant potential for the precision processing of titanium alloys. However, prior studies have primarily focused on surface roughness, while comprehensive experimental investigations remain limited. Moreover, the underlying mechanisms have yet to be explored. To address these research gaps, comprehensive MRSTP experiments are conducted on Ti-6Al-4V using a multi-pole coupling magnetic field, considering surface roughness, polishing force, and material removal rate. The optimal parameters are determined, including a carrier fluid concentration of 20 wt%, an abrasive concentration of 7.5 wt%, an abrasive size of 13 μm, a carbonyl iron particle size of 50 μm, a magnetic flux density of 140 mT, a feed rate of 6000 mm/min, and a spindle speed of 100 r/min. After 60 min of MRSTP under these conditions, the surface roughness is reduced from approximately 280 to 24 nm, achieving a mirror-like appearance. The normal and tangential forces are measured to be 4.04 and 1.74 N, respectively, with a corresponding material removal rate of 24.3 mg/h. The formation of enhanced particle clusters explains the underlying mechanisms for these variations. This study provides valuable insights into tailoring MRSTP strategies for specific difficult-to-machine materials and into understanding the MRSTP mechanism. 1 | Introduction Titanium alloys, particularly Ti-6Al-4V, have attracted significant attention in advanced ma

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Small non-coding RNAs as diagnostic, prognostic and predictive biomarkers of gynecological cancers: an update

Introduction: Non-coding RNAs (ncRNAs) comprise a heterogeneous cluster of RNA molecules. Emerging evidence suggests their involvement in various aspects of tumorigenesis, particularly in gynecological malignancies. Notably, ncRNAs have been implicated as mediators within tumor signaling pathways, exerting their influence through interactions with RNA or proteins. These findings further highlight the hypothesis that ncRNAs constitute therapeutic targets and point out their clinical potential as stratification biomarkers. Areas Covered: The review outlines the use of small ncRNAs, including miRNAs, tRNA-derived small RNAs, PIWI-interacting RNAs and circular RNAs, for diagnostic, prognostic, and predictive purposes in gynecological cancers. It aims to increase our knowledge of their functions in tumor biology and their translation into clinical practice. Expert Opinion: By leveraging interdisciplinary collaborations, scientists can decipher the riddle of small ncRNA biomarkers as diagnostic, prognostic and predictive biomarkers of gynecological tumors. Integrating small ncRNA-based assays into clinical practice will allow clinicians to provide cure plans for each patient, reducing the likelihood of adverse responses. Nevertheless, addressing challenges such as standardizing experimental methodologies and refining diagnostic assays is imperative for advancing small ncRNA research in gynecological cancer. ARTICLE HISTORY Received 7 May 2024 Accepted 22 September

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Real-Time Rice Crop Disease Monitoring: YOLOv11-Powered System with Voice Alerts and Health Scoring

This paper presents a cost-efficient, AI-driven framework for real-time detection and alerting of rice crop diseases using YOLOv11. The proposed system addresses the limitations of existing solutions by leveraging existing low-cost field cameras or drone/UAV-captured images with geotagged metadata, eliminating the need for new camera infrastructure and reducing costs significantly. The YOLOv11 model is employed for multi-class detection of Bacterial Blight, Rice Blast, and Brown Spot, achieving a Box Precision (P) of 0.649, Box Recall (R) of 0.569, mAP50 of 0.626. The system integrates with a localized Interactive Voice Response (IVR) system for voice alerts and includes a field health scoring mechanism to provide actionable insights to farmers. The web-based dashboa rd health scores, upcoming risks like disease and alert logs, enabling farmers to monitor crop health remotely. Simulated case studies demonstrate the system's effectiveness in generating relevant alerts and tracking health scores over time. Future work will focus on improving model recall and mAP50-95 through further training with augmented datasets and expanding detection capabilities to include more diseases. This framework represents a significant advancement in AI-driven agricultural solutions for small-scale farmers, offering a powerful tool to enhance rice crop management and improve food security.

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